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KMID : 0043320120350020367
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Archives of Pharmacal Research
2012 Volume.35 No. 2 p.367 ~ p.373
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Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation
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Kim Jae-Wook
Kim Chung-Soo
Hu Zhenzhen
Han Jin-Yi
Kim Si-Kwan
Yoo Sung-Kwang
Yeo Yeong-Man
Chong Myong-Soo
Lee Ki-Nam
Hong Jin-Tae
Oh Ki-Wan
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Abstract
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This experiment was performed to investigate whether apigenin has hypnotic effects and/or enhances pentobarbital-induced sleep behaviors through the GABAergic systems. Apigenin prolonged sleep time induced by pentobarbital similar to muscimol, a GABAA receptors agonist. Apigenin also increased sleep rate and sleep time in the combined administration with pentobarbital at the sub-hypnotic dosage, and showed synergic effects with muscimol in potentiating sleep onset and enhancing sleep time induced by pentobarbital. In addition, both of apigeinin and pentobarbital increased chloride influx in primary cultured cerebellar granule cells. Apigenin increased glutamate decarboxylase (GAD) and had no effect on the expression of GABAA receptorα-, β-, γ-subunits in n hippocampus of mouse brain, showing different expression of subunits from pentobarbital treatment group. In conclusion, it is suggested that apigenin augments pentobarbital-induced sleep behaviors through chloride ion channel activation.
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KEYWORD
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Apigenin, Pentobarbital, Muscimol, GABA, Sleep, GAD
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